The Pac-12 went 8-3 on opening weekend, including a 2-2 record against the Mountain West.
This week the conference will be tested more nationally with three games against Big Ten competition and matchups with the ACC, Big East and SEC.
And, of course, the Buffs do battle with a Big Sky opponent for the third time in six years.
Here are my Week 2 picks sure to go wrong:
Utah (1-0) at Utah State (1-0) at Romney Stadium in Logan (6 p.m. ESPN2).
The Utes will not have an easy time against their long-time in-state rivals but improve to 88-28-4 in the series with a 27-24 victory.
Southern Utah (0-1) at Cal (0-1) at Memorial Stadium in Berkeley (1 p.m., Pac-12 Networks).
The Bears bounce back from the loss to Nevada and roll, 40-14.
Eastern Washington (1-0) at Washington State (0-1) at Martin Stadium in Pullman (1 p.m., Pac-12 Networks).
Eastern Washington beat Idaho in nearby Moscow last week, but Mike Leach gets first win as Cougars coach here in a tight one, 30-27.
Illinois (1-0) at Arizona State (1-0) at Sun Devil Stadium in Tempe (8:30 p.m., ESPN).
The Sun Devils avenge last year’s 17-14 loss at Illinois with a 34-28 home win.
No. 18 Oklahoma State (1-0) at Arizona (1-0) at Arizona Stadium in Tucson (8:30 p.m., Pac-12 Networks).
He’s a man and Mike Gundy will hang 40 on Rich Rodriguez. Cowboys cruise, 45-30.
Duke (1-0) at No. 25 Stanford (1-0) at Stanford Stadium in Palo Alto (8:30 p.m., Pac-12 Networks).
These aren’t Mike Krzyzewski’s Blue Devils. Cardinal wins 27-17.
No. 2 USC (1-0) at Syracuse (0-1) at Met Life Stadium in East Rutherford, N.J. (1:30 p.m., ABC).
Trojans will make a statement after slipping to No. 2 in the polls. Orange crushed, 42-20.
No. 13 Wisconsin (1-0) at Oregon State (0-0) at Reser Stadium in Corvallis (2 p.m., FX).
The Beavers have a chance to pull off an upset here, but the Badgers get it done on the road with their running game. Wisconsin grinds out a 31-27 win.
Fresno State (1-0) at No. 4 Oregon (1-0) at Atzun Stadium in Eugene (4:30 p.m., Pac-12 Networks).
The Bulldogs will be licking their wounds when CU comes calling next week. Ducks dominate, 50-20.
Washington (1-0) at No. 3 LSU (1-0) at Tiger Stadium in Baton Rogue (5 p.m., ESPN).
Kudos to the Huskies for playing a game in SEC country. But LSU’s defense is too much for Steve Sarkisian and Co. as the Tigers win 32-17.
No. 16 Nebraska (1-0) at UCLA (1-0) at the Rose Bowl in Pasadena (5:30 p.m., Fox).
Big Red invades the Rose Bowl and stays on track for a return trip after a 29-23 win over the Bruins.
Sacramento State (0-1) at Colorado (0-1) at Folsom Field in Boulder (1 p.m., Pac-12 Networks).
I think the Buffs would beat New Mexico State with ease. The Hornets are coming off a 30-point loss in Las Cruces. CU picks up a 38-17 victory.
My season record: 10-1 (.909)